March 6, 2035 -- four and half years since cyber-cop Matoko Kusanagi joined with an artifical intelligence and quit the 9^th Police Squad. Now, a hyper-advanced cyborg called Motoko Aramaki -- a fusion of multiple entities and identities -- heads the investigative department of the giant multi-national, Poseidon Industrial, deploying remotely controlled humanoid surrogates around the globe as on-the-ground agents. When a herd of specially-bred pigs used to clone human organs for transplant are slaughtered, Motoko dispatches herself through cyberspace and utilizing surrogate cyborgs at far-flung locales to do the heavy lifting, Matoko hunts down the attackers, battling online and on the ground, but there may be more to the mystery than meets the eye...even the all-seeing eye of artificial intelligence. No work of graphic fiction you've ever experienced can prepare you for the mind-warping journey that is Man-Machine Interface.